Bio Hacks

Would this be for use in adult humans or is it just meant to edit embryos?  There is a problem of delivery of sgRNAs to neurons it's not feasible with the BBB (blood brain barrier).  Of course you can access the brain other ways more intrusively.  Although I have not researched this topic before I have found a few interesting details.  Amyloid beta (Aβ) has been theorized to be able to mitigate excessive calcium levels which are toxic to neurons but Aβ has been shown to be the cause of cerebral blood flow restriction as in (Fig 3) .  Of note, current trials focus on decreasing Aβ production such as the use of LY-450139, a gamma-secretase inhibitor.  Perhaps Inhibition of GSK3 whilst Aβ  levels are high via administration of HA-FGL (modified FG loop peptide) would result in neurogenesis, increased AMPA receptor density, increased dendritic arborization and synapse formation leading to remodeling and repair of lost cognitive function in the diseased brain.    Interestingly